Euphorbia celastroides var. lorifolia is a shrub or small tree that grows between 0.4 and 9 meters tall. Its stems, which range from prostrate to erect and measure 1 to 6 mm in diameter, are pubescent with flowering branches, often appearing nodose. The leaves are simple, opposite, and distichous with blades that are oblong, obovate, oblanceolate, elliptic, or linear, measuring 4 to 70 millimeters in length and 3 to 30 mm in width, sometimes extending up to 80 by 40 mm. These leaves have an acute to obtuse, retuse, or mucronulate apex and a cuneate to obtuse, oblique base. While the upper surfaces are glabrous, the lower surfaces can be glabrous, pilose, or villous, occasionally exhibiting a glaucous appearance. The entire margins are complemented by 0.5 to 5 mm long petioles, potentially up to 6 mm, varying from glabrous to villous. Stipules are acute to rounded-triangular, measuring 1 to 4 mm, sometimes up to 6 mm, and can be glabrous to villous, erose, and ciliate. The flowers are in a cyathia arranged in short or open-branched cymes or solitarily in leaf axils. The peduncles are 0.5 to 10 mm long, up to 19 mm, and vary from glabrous to villous. The involucre is campanulate, sized 1 to 3 mm high and 2 to 4 mm wide, displaying a glabrous to villous texture with 4 to 5 glands that are green or red, ranging from glabrous to pilose. The flowers, which are unisexual and highly reduced, feature solitary pistillate flowers on a gynophore and staminate flowers grouped in 5 cymules, each containing one to several flowers. It lacks both sepals and petals, with male flowers simplifying to a single stamen attached at the pedicel and filament junction, accompanied by slender bracteoles. The ovary is superior, with styles that are yellow, green, or red, bifid to varying extents, measuring 0.5 to 1 mm long, occasionally up to 1.5 mm, and varying from glabrous to pubescent, topped by a thickened stigma. The fruit are green to brown capsules, ovoid to rounded-triangular, 0.5 to 4 mm long, and glabrous to pubescent. Gynophores stand erect and protrude 0.5 to 1 millimeter from the involucre. The seeds are brown to gray, measuring approximately 1.5 mm, tetragonal to obcompressed, and have a surface texture that ranges from smooth to rugose. It occurs in mesic forests and thrives at elevations between 300-1500 meters.