Neraudia sericea is a shrub that grows to 3–5 meters high. The branches are densely pubescent, with short suberect hairs contributing to its distinctive texture. The leaves are simple and alternate, with narrowly elliptic to broadly ovate or sometimes elliptic-obovate blades measuring 4.3–13 cm in length and 2–5 cm in width. The apex of each leaf is abruptly long-acuminate to acute, while the base can be cuneate, rarely broadly so. The upper surfaces of the leaves are moderately appressed pubescent, including a tuft of hairs at the leaf base that is appressed; the lower surfaces are densely covered with silky, short-pilose hairs that are irregularly curved, grayish to white, and measure 0.2–0.5 mm in length, with some along the veins reaching up to 1 mm. These leaves are thin or relatively thick and contain disciform cystoliths. The edges are typically entire, though young leaves may show a few teeth. Palmately 3-veined from the base, the petioles are 0.8–5 cm long and densely covered with spreading hairs. Stipules are small and intrapetiolar. It is dioecious, with flowers occurring in axillary clusters. Staminate (male) flowers are borne on pedicels 0–2 mm long, while pistillate (female) flowers are sessile. The calyx of staminate flowers is densely pubescent with both appressed or spreading hairs and short, erect, uncinate hairs. The calyx lobes are boat-shaped, 3–3.5 mm long, slightly reflexed, and coherent in bud but separate at anthesis. The pistillate calyx lobes form a perigynium that is densely pubescent with appressed hairs and a few shorter, erect, uncinate hairs; the apex is 4-toothed, collar-like, or laciniate. The corolla is absent in both flower types. Staminate flowers feature staminal filaments that are elastically folded in bud and reflex when shedding pollen, and reniform anthers that open by longitudinal slits to release white pollen. The ovary in pistillate flowers is superior, pseudomonomerous (one fertile carpel and more or less prominent traces of sterile carpel(s)), and 1-celled with a single basal ovule; the style is singular, and the stigma is 3–5 mm long, receptive all around. The fruit is an achene, measuring 1.5–2 mm in length, with a depressed-conical apical portion and a deep constriction separating it from the basal portion. Each achene contains a single ovoid seed featuring a transverse constriction in the upper half. It is found predominantly in mesic to dry forests between 670-980 meters.