Peperomia latifolia is a fleshy herb characterized by its pale to dark red or reddish-green stems that are ascending or weakly erect from a short repent base. It ranges from 1.5 to 20 cm in height with a stem diameter of 2 to 8 mm at the base. The leaves are simple, varying in arrangement from alternate or opposite at the lower part of the stem to opposite or whorled at the upper part. Leaf blades vary in shape, ranging from elliptic-obovate to subrhombic-obovate, broadly elliptic, orbicular, and sometimes subspatulate, measuring 3 to 7.5 cm in length and 1.5 to 6.5 cm in width. The apex of the leaves is typically rounded to very broadly obtuse, with a base that ranges from truncate to rounded. Leaf surfaces are glabrous except usually hirsute toward the base and along the midrib, with the upper surfaces yellowish green and the lower surfaces whitish green, occasionally showing red intercostal areas. The leaves are relatively firm and dry chartaceous. The petioles are 0.7 to 3 cm long, hirsute, and occasionally sparsely so. The flowers are arranged in fleshy spikes, 1.5 to 15 cm long, and can be found terminally, axially, or leaf-opposed. The rachis is 2 to 3 mm in diameter and glabrous, with moderately congested flowers on peduncles that are 0.5 to 2.8 cm long and hirsute. The flowers are bisexual, lacking both a perianth and calyx, and do not have petals. A peltate bract subtends each flower, and it has two stamens. The ovary is superior, ovoid, and 1-carpellate. The fruit is broadly ovoid, measuring 0.7 to 1 mm long, and is papillose-viscid with sessile glands. Each fruit contains a single seed with scanty endosperm and copious starchy perisperm. It is found in mesic valleys and mesic to wet forests between 100-1,860 meters.